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Table 4 Comparisons of optimised 3-level RSP Design, UDPs and Random Walk Design in estimation of LD 50 of YTX

From: The development of response surface pathway design to reduce animal numbers in toxicity studies

Design Dose (μg/kg BW) Proportion of dead mice LD50with 95% CI (μg/kg BW)
Multinomial outcome variable with 3-level RSP design 400 1/3 453 (380 – 513)
475 4/7
500 3/5
UDP of OECD 225 0/1 400 (198 – 977)
400 0/3
710 2/2
Simple UDP 225 0/6 400 (65.2 – 580)
400 3/6
710 2/3
Random walk design 225 0/6 400 (65.2 – 580)
400 3/6
710 2/3
  1. The results are expressed with 95% Confidence Intervals.