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Table 4 Comparisons of optimised 3-level RSP Design, UDPs and Random Walk Design in estimation of LD 50 of YTX

From: The development of response surface pathway design to reduce animal numbers in toxicity studies

Design

Dose (μg/kg BW)

Proportion of dead mice

LD50with 95% CI (μg/kg BW)

Multinomial outcome variable with 3-level RSP design

400

1/3

453 (380 – 513)

475

4/7

500

3/5

UDP of OECD

225

0/1

400 (198 – 977)

400

0/3

710

2/2

Simple UDP

225

0/6

400 (65.2 – 580)

400

3/6

710

2/3

Random walk design

225

0/6

400 (65.2 – 580)

400

3/6

710

2/3

  1. The results are expressed with 95% Confidence Intervals.