From: The development of response surface pathway design to reduce animal numbers in toxicity studies
Design | Dose (μg/kg BW) | Proportion of dead mice | LD50with 95% CI (μg/kg BW) |
---|---|---|---|
Multinomial outcome variable with 3-level RSP design | 400 | 1/3 | 453 (380 – 513) |
475 | 4/7 | ||
500 | 3/5 | ||
UDP of OECD | 225 | 0/1 | 400 (198 – 977) |
400 | 0/3 | ||
710 | 2/2 | ||
Simple UDP | 225 | 0/6 | 400 (65.2 – 580) |
400 | 3/6 | ||
710 | 2/3 | ||
Random walk design | 225 | 0/6 | 400 (65.2 – 580) |
400 | 3/6 | ||
710 | 2/3 |