Effect of CNX-011-67 on islet gene expression. mRNA levels of PDX1 (A), GCK (B), INS1 (C) and PC (D) in islets from sham control, n-STZ and n-STZ-CNX-011-67 rats were measured as mentined in the methods. The mRNA levels of all the genes were expressed relative to β-actin mRNA. Values represent mean ± S.E.M (n = 4). Statistical analysis was performed by Students t-test (Two-way, unpaired: * P < 0.05 and *** P < 0.001).