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Table 1 Phenotypic characterization of n-STZ rats (prior to treatment commencement)

From: CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients

 

Body weight (g)

Fasting glucose (mg/dl)

Fasting insulin (ng/ml)

Glucose AUC (OGTT) (mg/dl)*min

Insulin AUC (GSIS) (ng/ml)*min

Sham (n = 32)

202 ± 6

83 ± 3

0.31 ± 0.05

14791 ± 255

98 ± 8.6

n-STZ (n = 55)

203 ± 3

80 ± 1.7

0.17 ± 0.04*

31617 ± 931***

79 ± 5.14

  1. Statistical comparison between sham and n-STZ group was conducted by Students t-test (Two-way, unpaired: *p < 0.05 and ***p < 0.001).