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Table 1 Phenotypic characterization of n-STZ rats (prior to treatment commencement)

From: CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients

  Body weight (g) Fasting glucose (mg/dl) Fasting insulin (ng/ml) Glucose AUC (OGTT) (mg/dl)*min Insulin AUC (GSIS) (ng/ml)*min
Sham (n = 32) 202 ± 6 83 ± 3 0.31 ± 0.05 14791 ± 255 98 ± 8.6
n-STZ (n = 55) 203 ± 3 80 ± 1.7 0.17 ± 0.04* 31617 ± 931*** 79 ± 5.14
  1. Statistical comparison between sham and n-STZ group was conducted by Students t-test (Two-way, unpaired: *p < 0.05 and ***p < 0.001).