TY - JOUR AU - Henderson, Lee W. AU - Dittrich, Howard C. AU - Strickland, Alan AU - Blok, Thomas M. AU - Newman, Richard AU - Oliphant, Thomas AU - Albrecht, Detlef PY - 2014 DA - 2014/01/25 TI - A Phase 1 dose-ranging study examining the effects of a superabsorbent polymer (CLP) on fluid, sodium and potassium excretion in healthy subjects JO - BMC Pharmacology and Toxicology SP - 2 VL - 15 IS - 1 AB - CLP is an orally administered, non-absorbed, superabsorbent polymer being developed to increase fecal excretion of sodium, potassium and water in patients with heart failure and end-stage renal disease. This study was conducted to evaluate the safety of CLP, and to explore dose-related effects on fecal weight, fecal and urine sodium and potassium excretion, and serum electrolyte concentrations. SN - 2050-6511 UR - https://doi.org/10.1186/2050-6511-15-2 DO - 10.1186/2050-6511-15-2 ID - Henderson2014 ER -