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Table 3 Baseline blood pressure factors associated with antihypertensive drug changes, CoLaus study

From: Antihypertensive drug treatment changes in the general population: the colaus study

  Continuers Combiners Switchers Discontinuers p-value
N 420 (54.4) 208 (26.9) 98 (12.7) 46 (6.0)  
BP status baseline      
 SBP (mm Hg) 137 ± 17 146 ± 19 138 ± 16 137 ± 15 <0.001
 DBP (mm Hg) 83 ± 11 86 ± 12 83 ± 11 83 ± 9 <0.05
 Hypertension§ 220 (52.4) 138 (66.4) 54 (55.1) 20 (43.5) <0.001
Antihypertensive drug      
 Diuretics (%) 236 (56.2) 64 (30.8) 47 (48.0) 15 (32.6) <0.001
 Beta-blockers (%) 120 (28.6) 50 (24.0) 30 (30.6) 16 (34.8) 0.38
 CCB (%) 76 (18.1) 42 (20.2) 23 (23.5) 5 (10.9) 0.30
 ACE inhibitors (%) 119 (28.3) 58 (27.9) 32 (32.7) 13 (28.3) 0.84
 ARBs (%) 224 (53.3) 82 (39.4) 26 (26.5) 13 (28.3) <0.001
Treatment regimen (%)      
 One pill, single drug 155 (36.9) 132 (63.5) 49 (50.0) 32 (69.6)  
 One pill, combination 119 (28.3) 34 (16.4) 26 (26.5) 7 (15.2) <0.001
 Several pills 146 (34.8) 42 (20.2) 23 (23.5) 7 (15.2)  
  1. Results are expressed as mean ± standard deviation or as number of participants and (percentage). §defined as a systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg if absence of diabetes, or as a systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥80 mm Hg if presence of diabetes. CCB, calcium channel blockers; ACE, angiotensin converting enzyme; ARB, angiotensin receptor blockers. Statistical analysis comparing all groups by Chi-square or one-way analysis of variance.