Table 2 Initial meropenem pharmacokinetic parameters
From: Assessment of pharmacokinetic changes of meropenem during therapy in septic critically ill patients
Patient N° | V ss | V ss/weight | V ss2/V ss | AUC | Cl | T1/2 | Peak | Trough | T > 2 mg/L | T > 4 mg/L | T > 8 mg/L |
|---|---|---|---|---|---|---|---|---|---|---|---|
L | L/Kg | % | L/mg.h | mL/min | h | mg/L | mg/L | 100% | 90% | 70% | |
1 | 19.6 | 0.25 | 50.6% | 157.1 | 106.7 | 2.9 | 63.3 | 3.0 | 100% | 100% | 100% |
2 | NA | NA | NA | 264.7 | 63.3 | 1.5 | NA | 11.9 | 100% | 100% | 100% |
3 | 13.6 | 0.21 | 56.3% | 253.3 | 65 | 2.6 | 94.1 | 8.6 | 100% | 100% | 85% |
4 | 13.6 | 0.17 | 78.4% | 160.1 | 103.3 | 1.7 | 102.3 | 4.8 | 100% | 85% | 50% |
5 | 13.4 | 0.16 | 51.8% | 129.2 | 128.3 | 1.3 | 80.1 | 2.7 | 100% | 90% | 65% |
6 | 32.7 | 0.42 | 93.7% | 134.9 | 123.3 | 3.4 | 52.0 | 3.0 | 100% | 100% | 100% |
7 | 18.6 | 0.23 | 73.6% | 479.2 | 35 | 6.4 | 84.7 | NA | 100% | 100% | 100% |
8 | 14.9 | 0.25 | 88.7% | 465.9 | 35 | 5.0 | 91.3 | NA | 100% | 100% | 75% |
9 | 6.7 | 0.07 | 90.4% | 232.5 | 71.7 | 1.4 | 192.5 | 4.4 | 100% | 75% | 50% |
10 | 13.0 | 0.16 | 58.4% | 139.5 | 120 | 1.5 | 85.1 | 2.4 | 100% | 75% | 50% |
11 | 20.9 | 0.30 | 68,6% | 107.3 | 155 | 1.9 | 58.6 | 2.9 | 100% | 100% | 100% |
12 | 13.6 | 0.18 | 79.2% | 304.2 | 55 | 3.5 | 119.8 | 8.6 | 75% | 50% | 35% |
13 | 17.1 | 0.27 | 34.9% | 81.4 | 205 | 1.3 | 56.9 | 0.6 | 100% | 100% | 55% |
14 | 22.5 | 0.28 | 53.1% | 120.7 | 138.3 | 2.1 | 48.4 | 4.1 | 100% | 100% | 100% |
15 | 13.0 | 0.13 | 68.6% | 315.3 | 53.3 | 3.3 | 124.2 | 12.5 | 100% | 90% | 70% |
Geometric mean | 15.7 | 0.2 | 63.1% | 190.2 | 73.3 | 2.3 | 85.9 | 3.8 | 100% | 100% | 100% |
95% CI | 12.7-19.4 | 0.15-0.27 | 52.7-75.5% | 138.4-261.4 | 45-120 | 1.8-3.1 | 69.2-106.6 | 2.3-6.2 |