Drug exposures | Cardiovascular disease cohort | Acute myocardial infarction cohort | ||
---|---|---|---|---|
 | Death | Cardiovascular disease | Death | Cardiovascular disease |
 | §HR (95% CI) | §HR (95% CI) | §HR (95% CI ) | §HR (95% CI) |
Total cohort | Â | Â | Â | Â |
Current clopodogrel and PPI** (reference) | 1.00 | 1.00 | 1.00 | 1.00 |
No PPI and no clopidogrel | 2.36 (1.39-4.00) | 1.54 (1.05-2.24) | 3.13 (1.47-6.68) | 1.77 (0.92-3.41) |
Current only PPIs | 2.02 (1.19-3.44) | 1.11 (0.75-1.65) | 1.93 (0.91-4.11) | 1.02 (0.52-1.99) |
Current only clopidogrel | 1.14 (0.53-2.45) | 1.80 (1.15-2.83) | 1.88 (0.70-5.03) | 1.88 (0.85-4.08) |
Patients with diagnosis of bleeding before entry* | Â | Â | Â | Â |
Current clopodogrel and PPI(reference) | 1.00 | 1.00 | 1.00 | 1.00 |
No PPI and no clopidogrel | 2.30 (1.33-3.98) | 1.54 (0.98-2.40) | 3.30 (1.47-7.41) | 1.65 (0.78-3.47) |
Current only PPI | 2.05 (1.18-3.54) | 1.04 (0.65-1.65) | 2.12 (0.95-4.73) | 0.80 (0.37-1.72) |
Current only clopidogrel | 1.25 (0.57-2.72) | 1.84 (1.07-3.16) | 2.26 (0.82-6.26) | 1.78 (0.70-4.57) |