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Table 1 Preischemic and postischemic recovery of contractile function

From: Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury

  Preischemic Postischemic recovery
 i2 fl-G184S/fl-G184S + tamoxifen (n = 6) Cre-ERT2/Gαi2 fl-G184S/fl-G184S + tamoxifen (n = 6) Cre-ERT2/Gαi2 fl-G184S/fl-G184S
+ vehicle (n = 4)
i2 fl-G184S/fl-G184S + tamoxifen (n = 6) Cre-ERT2/Gαi2/fl-G184S/fl-G184S + tamoxifen (n = 6) Cre-ERT2/Gαi2 fl-G184S/fl-G184S + vehicle (n = 4)
Developed pressure (mmHg) 130 ± 6 140 ± 8 132 ± 6 45 ± 5 78 ± 8 * # 29 ± 7
+dP/dT (mmHg/sec) 6375 ± 570 6145 ± 621 4587 ± 251 2223 ± 321 3557 ± 521 # 985 ± 258
-dP/dT (mmHg/sec) -4471 ± 291 -4601 ± 275 -3837 ± 235 -1600 ± 197 -2581 ± 263 * # -908 ± 243
End diastolic pressure (mmHg) 5.7 ± 1.0 6.2 ± 0.9 5.0 ± 1.0 30 ± 2 21 ± 3 33 ± 7
Coronary flow rate (ml/min) 4.5 ± 0.4 4.1 ± 0.3 4.6 ± 0.4 2.7 ± 0.3 2.6 ± 0.2 2.9 ± 0.4
  1. Preischemic contractile function was measured prior to 30 minutes of ischemia. Postischemic recovery of contractile function was measured following 1 hour of reperfusion. Data from each group were compared by one way ANOVA and posthoc Tukey analysis (preischemic and postischemic values were analyzed separately from one another). There were no significant differences between groups for any parameters of preischemic contractile function. *indicates a significant difference (p < 0.05) in postischemic recovery of contractile function compared to hearts isolated from tamoxifen treated Gαi2 fl-G184S/fl-G184S mice. # indicates a significant difference (p < 0.01) in postischemic recovery of contractile function compared to hearts isolated from Cre-ERT2/Gαi2 fl-G184S/fl-G184S mice that were treated with vehicle instead of tamoxifen.