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Table 4 Logistic regression analysis of selected variables and adverse drug reactions to ART, ART clinic, Gondar University Hospital, June 2012

From: Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV infected patients: a cross sectional study

Variables Total (N)* Self-reported ADRs**(≥3), n = 229 OR (95% CI)*** P value AOR( 95% CI)
Age  
≤ 40 years 327 192(58.7) 1   
>40 years 57 37(64.9) 1.28(0.69, 2.38) 0.44  
Gender  
Female 257 152(59.1) 1   
Male 127 77(60.6) 1.06 (0.69, 1.64) 0.78  
Education  
Illiterate 97 58(59.8) 1   
≥primary 287 171(59.6) 0.92 (0.58, 1.46) 0.72  
Work status  
Employed 149 78(52.3) 1   1
Non-employed 235 151(64.2) 1.82 (1.17, 2.84) <0.01 1.76 (1.15, 2.70)a
Marital status  
Married 212 121(57.1) 1   
Non- married 172 108(62.8) 1.16 (0.75, 1.82) 0.50  
Residency  
Urban 346 211(61.0) 1   
Rural 38 18(43.4) 0.58(0.28, 1.18) 0. 14  
Duration of ART  
≤4 years 155 85(54.8) 1   
>4 years 229 144(62.9) 1.39 (0.92, 2.21) 0.11  
ART treatment change  
Yes 78 42(53.8) 1   
No 306 187(61.1) 1.35(0.82,2.22) 0.24  
Current CD4 level  
≤350 181 107(59.1) 0.96(0.64, 1.44) 0.85  
>350 203 122(60.1) 1   
Current ART regimen  
AZT backbone 204 122(59.8) 1.01(0.67, 1.53) 0.94  
Non-AZT backbone 180 107(59.4) 1   
Adherence  
Yes 370 223(60.3) 1   
No 14 6(42.8) 0.50(0.17, 1.45) 0.2  
ADR duration (self-reported)  
≤1 month 212 140(66.0) 1.81(1.20, 2.74)   1.95(1.28,2.98)b
>1 month 172 89(51.7) 1 <0.01 1
  1. *Percent frequency that refers to the total number of patients (N = 384). **Number and proportion of patients’ self-reporting 3 or more adverse drug reactions. ***Values represent odds ratio (OR) at 95% confidence interval. Values represent adjusted odds ratio (AOR) at 95% confidence interval, ap = 0.01, bp = 0.001.