Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV infected patients: a cross sectional study

Table 4 Logistic regression analysis of selected variables and adverse drug reactions to ART, ART clinic, Gondar University Hospital, June 2012

Variables	Total (N)^*	Self-reported ADRs^**(≥3), n = 229	OR (95% CI)^***	P value	AOR( 95% CI)^†
Age
≤ 40 years	327	192(58.7)	1
>40 years	57	37(64.9)	1.28(0.69, 2.38)	0.44
Gender
Female	257	152(59.1)	1
Male	127	77(60.6)	1.06 (0.69, 1.64)	0.78
Education
Illiterate	97	58(59.8)	1
≥primary	287	171(59.6)	0.92 (0.58, 1.46)	0.72
Work status
Employed	149	78(52.3)	1		1
Non-employed	235	151(64.2)	1.82 (1.17, 2.84)	<0.01	1.76 (1.15, 2.70)^a
Marital status
Married	212	121(57.1)	1
Non- married	172	108(62.8)	1.16 (0.75, 1.82)	0.50
Residency
Urban	346	211(61.0)	1
Rural	38	18(43.4)	0.58(0.28, 1.18)	0. 14
Duration of ART
≤4 years	155	85(54.8)	1
>4 years	229	144(62.9)	1.39 (0.92, 2.21)	0.11
ART treatment change
Yes	78	42(53.8)	1
No	306	187(61.1)	1.35(0.82,2.22)	0.24
Current CD4 level
≤350	181	107(59.1)	0.96(0.64, 1.44)	0.85
>350	203	122(60.1)	1
Current ART regimen
AZT backbone	204	122(59.8)	1.01(0.67, 1.53)	0.94
Non-AZT backbone	180	107(59.4)	1
Adherence
Yes	370	223(60.3)	1
No	14	6(42.8)	0.50(0.17, 1.45)	0.2
ADR duration (self-reported)
≤1 month	212	140(66.0)	1.81(1.20, 2.74)		1.95(1.28,2.98)^b
>1 month	172	89(51.7)	1	<0.01	1

^*Percent frequency that refers to the total number of patients (N = 384). ^**Number and proportion of patients’ self-reporting 3 or more adverse drug reactions. ^***Values represent odds ratio (OR) at 95% confidence interval. ^†Values represent adjusted odds ratio (AOR) at 95% confidence interval, ^ap = 0.01, ^bp = 0.001.