Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV infected patients: a cross sectional study

Table 5 Impacts of self-reported ADRs on perception of treatment and social interaction, ART clinic, Gondar University Hospital, June 2012

Variables	n (%)	Association of variables with specific ADRs (chi-square or fisher test)
		Nausea	Headache	Fever	Vomiting	Lethargy	Loss of appetite	Insomnia	Depression	Night mare	Diarrhea	OU/DM
Impacts on patients perception on treatment patients who:
Decided to skip medication due to ADRs^*	10 (2.6)	0.54	0.51	0.35	0.55	0.26	0.48	0.20	0.21	0.42	0.78	0.26
Consider ART unsuccessful due to ADRs^**	114 (31.0)	1.43	0.10	7.42^b	5.00^a	29.53^c	25.93 ^c	14.47 ^c	24.43^c	1.43	13.63^c	13.70^c
Impacts of ADR on patients’ social interaction patients who:
Perceive that people avoid them due to observed ADRs^**	21 (32.9)	5.68 ^a	0.76	11.97^c	12.7^c	28.13^c	26.67 ^c	18.28 ^c	23.15^c	3.19^a	8.45^b	14.94^c
Tend to reduce/avoid social interaction because of ADRs^**	119 (32.2)	2.11	0.26	9.87 c	7.96^b	33.20	26.67^c	20.88 _c	3.40^c	1.87	8.45^b	6.70 ^c
Perceive family members avoid them when ADRs occurred ^**	57 (15.4)	0.99	3.35^a	2.19	0.06	0.08	1.01	0.45	3.40^a	0.03	0.99	6.70^b
Talk to family members about ADRs as it appears^**	296 (80.0)	14.32^c	10.24^c	5.92 ^b	7.73^b	4.34^a	2.84	0.61	2.21	0.31	0.01	0.62

n = 384. ^*Fishers exact test, ^**chi-square test was used to assess associations. ^asignificant at a level of p < 0.05, ^bsignificant at a level of p < 0.01, ^csignificant at a level of p < 0.001. OU/DM, oral ulceration or dry mouth.