Transcriptional regulation of kinases downstream of the T cell receptor: another immunomodulatory mechanism of glucocorticoids

Table 1 Summary of kinase modulation following dexamethasone treatment

		Effect of dexamethasone treatment
		In vitro 3 h treatment	In vivo 3 h treatment (25 mg/kg)	In vivo 6 h treatment (25 mg/kg)
Thymocytes	Itk	↑↑↑	↑↑	↑↑↑
	Txk	↑	=	=
	Lck	↓↓	↓↓↓	↓↓↓
Lymphocytes from peripheral organs	Itk	↑↑↑	↑↑↑	=
	Txk	↑↑	↑↑	↑↑↑
	Lck	=	=	↑↑

=,gene expression difference between treated and medium-treated samples/animals is not significant;
↑ or ↓,The difference between treated and untreated samples is significant and has a fold modulation (increase or decrease) lower than 1.6 or higher than -1.6.
↑↑ or ↓↓,The difference between treated and untreated samples is significant and has a fold modulation comprised between 1.6 and 2.2 or -1.6 and -2.2.
↑↑↑ or ↓↓↓,The difference between treated and untreated samples is significant and has a fold modulation higher than 2.2 or lower than -2.2.

ISSN: 2050-6511