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Table 3 Relative mRNA concentrations of PPARα and PPARδ target genes involved in β-oxidation (ACOX1, SCAD, MCAD, LCAD) and genes involved in carnitine uptake (OCTN2) and biosynthesis (BBD, TMABA-DH) in liver and gastrocnemius muscle of lean rats (Lean), obese Zucker rats fed a control diet (Obese Control) or obese Zucker rats fed a diet supplemented with 780 mg niacin/kg diet (Obese Niacin) for 4 wk 1

From: Pharmacological doses of niacin stimulate the expression of genes involved in carnitine uptake and biosynthesis and improve the carnitine status of obese Zucker rats

  Lean Obese control Obese niacin
  Relative mRNA concentration (fold of obese control = 1.00)
Skeletal muscle    
ACOX1 1.49 ± 0.29ab 1.00 ± 0.21b 1.89 ± 0.36a
SCAD 1.68 ± 0.46ab 1.00 ± 0.40b 2.69 ± 0.70a
MCAD 1.40 ± 0.30ab 1.00 ± 0.34b 2.24 ± 0.47a
LCAD 1.43 ± 0.46ab 1.00 ± 0.25b 3.78 ± 1.32a
SLC22A5 1.25 ± 0.31ab 1.00 ± 0.18b 1.93 ± 0.42a
Liver    
ACOX1 0.92 ± 0.14b 1.00 ± 0.12b 1.42 ± 0.07a
SCAD 0.91 ± 0.09b 1.00 ± 0.14b 1.57 ± 0.08a
MCAD 1.19 ± 0.13b 1.00 ± 0.14b 1.76 ± 0.22a
LCAD 0.99 ± 0.17b 1.00 ± 0.14b 1.57 ± 0.08a
SLC22A5 0.78 ± 0.06b 1.00 ± 0.07b 1.42 ± 0.12a
BBOX1 0.76 ± 0.08b 1.00 ± 0.08b 1.54 ± 0.06a
ALDH9 1.00 ± 0.08b 1.00 ± 0.08b 1.40 ± 0.14a
  1. 1Data are expressed as means ± SEM. n = 10 rats/group. a,bValues with different superscript letters differ, P < 0.05.
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