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Table 2 Mean (±SD) CLam/W a , CLcr b , V/W c and T½ d for amoxicillin in patients using amoxicillin/clavulanic acid broken down per age group

From: Is the standard dose of amoxicillin-clavulanic acid sufficient?

Age group in years

N

CLam/W in L/h/kg

CLcr in mL/min

V/W in L/kg

T½ in h

<70

31

0.19 (±0.08)

82 (±25)

0.30 (±0.06)

1.26 (±0.44)

>70

26

0.14 (±0.06)

55 (±19)

0.32 (±0.08)

1.83 (±0.71)

P-value

 

0.02

<0.01

0.82

<0.01

  1. aCLam/W: amoxicillin clearance corrected for bodyweight.
  2. bCLcr: creatinine clearance.
  3. cV/W: volume of distribution corrected for bodyweight.
  4. dT½: amoxicillin half life.
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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