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Figure 3 | BMC Pharmacology and Toxicology

Figure 3

From: A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits

Figure 3

Effect of CNX-010-49 on muscle glucose oxidation, proteolysis and mitochondrial biogenesis. C2C12 myotubes were treated with GPCI (25 mM Glucose, 500 μM Palmitate, 1 μM of Cortisone, 10 ng/ml of each inflammatory cytokines (TNFa, IL1 β and IFNγ)) for 18 h with or without 1 μM of CNX-010-49. Post 18 h, mRNA expression of PDK4 and TRIM63 (A & B) and mitochondrial gene ND1 (C) were measured as mentioned in Methods. All the values are expressed as Mean ± SEM. Statistical comparison was conducted by One-way ANOVA followed by Dunnett’s test (n = 6) (*P < 0.05, **P < 0.01 and ***P < 0.001).

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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