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Table 1 Effect of CNX-010-49 on pharmacodynamic activity

From: A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits

  Liver Skeletal muscle Adipose Brain
Time (h) 1 7 1 7 1 7 1 7
% inhibition with CNX-010-49 58 ± 2 24 ± 6 41 ± 4 44 ± 5 38 ± 7 42 ± 5 0 0
  1. After oral administration of CNX-010-49 at 30 mg/kg (single dose) to Swiss albino mice (n = 4 per time point), pharmacodynamic activity of CNX-010-49 at different time points was measured in liver, muscle, adipose and brain tissues ex vivo as described in Methods.