Figure 5

Metabolic pathways identified to be significantly regulated. The figure shows metabolic pathways and general regulation patterns observed in these, as identified by analysis of each chemical reactivity group. Chemical reactivity abbreviations: Add/El: Addition/elimination to carboxylic acid derivatives; Koor: Coordination bonds; MA: Michael addition or 1,4-Addition to a/b unsaturated carbonyl; NAR: nucleophilic aromatic substitution, PreH: Prehapten; Chemical activation (outside the skin); ProH: Prohapten; Enzymatic activation; SB: Schiff’s Base reaction; SN2: bimolecular nucleophilic substitution. * most significant genes in t-test of negative samples versus given chemical reactivity group. 1) Only pathways where at least one group gives a contribution of 2 times the significance threshold from IPA® were reported. ↑: 80% of transcripts or more up regulated, regulated transcripts ≥5. (↑): 80% of transcripts or more up regulated, regulated transcripts <5. ↓: 80% of transcripts or more down regulated, regulated transcripts ≥5. (↓): 80% of transcripts or more down regulated, regulated transcripts <5. MIX: a mix of up and down regulation, regulated transcripts ≥5. (MIX): a mix of up and down regulation, regulated transcripts <5. NC: No significant change compared to non-sensitizers.