Figure 6

Network of interactions between transcription regulators observed or predicted in the IPA® analysis of the 9 chemical reactivity groups. Observed expression patterns were analyzed using IPA® in order to predict upstream regulation. The prediction was based on the expression patterns of the chemical groups and only the most significant predictions were included here. The network shows the known interactions between the regulatory elements identified to be up or down regulated in the analysis. Red color indicates a observed/predicted activation and green color indicates a observed/predicted inhibition of the molecule or complex of molecules. All interactions are based on experimental evidence from the scientific literature. Arrow directions show which way the regulation is directed, if known. R: regulation; B: binding; Br: binding regulated by target; RR: bidirectional regulation; Tg: target. The network was extracted from the MetaCore™ database (Thomson Reuters). For details about observation/prediction state, see Additional files 2, 3, 4 and 5.