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Table 2 Rates of Yellow Card adverse reports per million prescriptions dispensed for the top 20 drugs with the highest number of adverse reports for depressive disorders, non-fatal suicidal behaviour and suicide

From: Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011

 

Drug

Number of reports

Overall rate per million prescriptions 1998-2011

95% confidence intervals

Depressive disorders

    

Non-nervous system drugs

Rimonabant

190

773

667-891

 

Isotretinoin

199

553

479-636

 

Mefloquine

105

457

373-553

 

Etonogestrel

51

82

61-108

 

Sibutramine

55

25

19-33

 

Levonorgestrel

86

14

12-18

 

Desogestrel

64

9

7-12

 

Rofecoxib

73

9

7-12

 

Montelukast

45

5

3-6

 

Atorvastatin

74

0.6

0.5-0.8

 

Simvastatin

110

0.4

0.3-0.5

Nervous system drugs

Clozapine

50

630

468-831

 

Bupropion*

483

330

301-361

 

Varenicline

975

248

233-264

 

Topiramate

61

18

14-23

 

Levetiracetam

66

15

12-19

 

Paroxetine

263

8

7-9

 

Venlafaxine

57

2

2-3

 

Fluoxetine

56

0.9

0.7-1.2

 

Citalopram

56

0.7

0.5-0.9

Non-fatal suicidal behaviour

    

Non-nervous system drugs

Rimonabant

74

30

236-378

 

Isotretinoin

71

197

154-249

Nervous system drugs

Clozapine

132

1664

1393-1973

 

Atomoxetine

126

230

192-274

 

Varenicline

675

172

159-185

 

Bupropion*

117

80

66-96

 

Duloxetine

97

32

26-39

 

Paroxetine

709

21

19-22

 

Levetiracetam

69

16

12-20

 

Topiramate

37

11

8-15

 

Pregabalin

47

6

5-8

 

Escitalopram

61

6

4-7

 

Venlafaxine

113

4

3-5

 

Risperidone

49

3

3-5

 

Mirtazapine

67

3

3-4

 

Olanzapine

48

3

2-4

 

Citalopram

219

3

2-3

 

Fluoxetine

161

3

2-3

 

Sertraline

51

2

1-3

 

Paracetamol

69

0.4

0.3-0.5

Suicide

    

Non-nervous system drugs

Efavirenz

7

2312

930-4757

 

Isotretinoin

32

89

61-126

 

Mefloquine

8

35

15-69

Nervous system drugs

Clozapine

78

984

778-1227

 

Varenicline

41

10

8-14

 

Duloxetine

28

9

6-13

 

Aripiprazole

15

9

5-14

 

Risperidone

24

2

1-3

 

Paroxetine

50

2

1-2

 

Venlafaxine

42

1

1-2

 

Olanzapine

24

1

0.9-2

 

Escitalopram

15

1

0.8-2

 

Quetiapine

13

1

0.6-2

 

Fluoxetine

58

0.9

0.7-1

 

Citalopram

70

0.8

0.7-1

 

Mirtazapine

17

0.8

0.5-1

 

Sertraline

21

0.8

0.5-1

 

Zopiclone

13

0.2

0.1-0.4

 

Diazepam

11

0.2

0.1-0.3

 

Amitryptiline

6

0.1

0.03-0.2

  1. *Bupropion is licensed for use as an antidepressant in other countries but not the UK.