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Table 2 Rates of Yellow Card adverse reports per million prescriptions dispensed for the top 20 drugs with the highest number of adverse reports for depressive disorders, non-fatal suicidal behaviour and suicide

From: Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011

  Drug Number of reports Overall rate per million prescriptions 1998-2011 95% confidence intervals
Depressive disorders     
Non-nervous system drugs Rimonabant 190 773 667-891
  Isotretinoin 199 553 479-636
  Mefloquine 105 457 373-553
  Etonogestrel 51 82 61-108
  Sibutramine 55 25 19-33
  Levonorgestrel 86 14 12-18
  Desogestrel 64 9 7-12
  Rofecoxib 73 9 7-12
  Montelukast 45 5 3-6
  Atorvastatin 74 0.6 0.5-0.8
  Simvastatin 110 0.4 0.3-0.5
Nervous system drugs Clozapine 50 630 468-831
  Bupropion* 483 330 301-361
  Varenicline 975 248 233-264
  Topiramate 61 18 14-23
  Levetiracetam 66 15 12-19
  Paroxetine 263 8 7-9
  Venlafaxine 57 2 2-3
  Fluoxetine 56 0.9 0.7-1.2
  Citalopram 56 0.7 0.5-0.9
Non-fatal suicidal behaviour     
Non-nervous system drugs Rimonabant 74 30 236-378
  Isotretinoin 71 197 154-249
Nervous system drugs Clozapine 132 1664 1393-1973
  Atomoxetine 126 230 192-274
  Varenicline 675 172 159-185
  Bupropion* 117 80 66-96
  Duloxetine 97 32 26-39
  Paroxetine 709 21 19-22
  Levetiracetam 69 16 12-20
  Topiramate 37 11 8-15
  Pregabalin 47 6 5-8
  Escitalopram 61 6 4-7
  Venlafaxine 113 4 3-5
  Risperidone 49 3 3-5
  Mirtazapine 67 3 3-4
  Olanzapine 48 3 2-4
  Citalopram 219 3 2-3
  Fluoxetine 161 3 2-3
  Sertraline 51 2 1-3
  Paracetamol 69 0.4 0.3-0.5
Suicide     
Non-nervous system drugs Efavirenz 7 2312 930-4757
  Isotretinoin 32 89 61-126
  Mefloquine 8 35 15-69
Nervous system drugs Clozapine 78 984 778-1227
  Varenicline 41 10 8-14
  Duloxetine 28 9 6-13
  Aripiprazole 15 9 5-14
  Risperidone 24 2 1-3
  Paroxetine 50 2 1-2
  Venlafaxine 42 1 1-2
  Olanzapine 24 1 0.9-2
  Escitalopram 15 1 0.8-2
  Quetiapine 13 1 0.6-2
  Fluoxetine 58 0.9 0.7-1
  Citalopram 70 0.8 0.7-1
  Mirtazapine 17 0.8 0.5-1
  Sertraline 21 0.8 0.5-1
  Zopiclone 13 0.2 0.1-0.4
  Diazepam 11 0.2 0.1-0.3
  Amitryptiline 6 0.1 0.03-0.2
  1. *Bupropion is licensed for use as an antidepressant in other countries but not the UK.