Pharmacokinetics and safety issues of an accidental overdose of 2,000,000 IU of vitamin D3 in two nursing home patients: a case report

Table 1 Biochemical values from single high-dose vitamin D3 administration in two cases

		Reference range	1 h	5.5 h	1d	2d	3d	4d	8d	11d	14d	22d	29d	36d	43d	60d	71d	106d
Case 1	Calcidiol (nmol/L)	50-200	59	224	395	448			527		522	403	323	318	283		203	131
	Calcium (mmol/L)	2.20-2.65	2.52	2.51	2.57	2.64	2.67	2.64	2.68		2.63	2.57	2.45	2.5	2.5		2.43	2.43
	Phosphate (mmol/L)	0.80-1.40	1.08	1.09	1.05	1.30	1.13	1.14	1.37		1.32	1.01	1.00	0.98	0.97			0.96
	Creatinine (μmol/L)	60-110	64	65	66	68	69	73	69		77	75	71	69	63	66	75	65
Case 2	Calcidiol (nmol/L)	50-200	77		326	354			422		405	363	322	324	255		233
	Calcium (mmol/L)	2.20-2.65	2.46		2.69	2.73	2.68	2.69	2.66	2.70	2.57	2.59	2.50	2.49	2.59		2.57
	Phosphate (mmol/L)	0.80-1.40	0.91		1.20	1.06	1.12	1.05	1.13	1.02	1.07	0.82	0.82	0.89	0.87		0.79
	Creatinine (μmol/L)	50-90	45		51	44	55	54	52	52	49	52	41	50	54		45

Values outside the reference range are indicated in bold. h, hours; d, days. Conversion factors: calcidiol (mg/dL = 0.4 × mmol/L), calcium (mg/dL = 4 × mmol/L), phosphate (mg/dL = 3.1 × mmol/L), creatinine (mg/dL = 0.01 × μmol/L).

ISSN: 2050-6511