Figure 2
From: Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation
Sample two-electrode voltage clamp recordings from oocytes expressing either GABA A receptors (left) or NMDA receptors (right). Black bars (▬) represent periods of agonist exposure, and arrows (↔) represent periods of saturated alkane exposure. Both butane and pentane positively modulate GABAA receptors. Butane negatively modulates NMDA receptors, but pentane produces no effect. Hence, NMDA receptors exhibit an alkane cut-off between butane and pentane.