Figure 5
From: Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation
Summary of receptor cut-off effects as a function of the calculated molecular volume of each drug for compounds tested in Tables 1 and 2 . For each hydrocarbon functional group, white bars represent compounds that modulate both GABAA and NMDA receptors, and black bars represent compounds that modulate GABAA receptors but have no effect on NMDA receptors at a saturating concentration. Intervening grey bars represent solubility values for which no data exist. No receptor cut-off pattern is evident as a function of molecular volume.