ADR types* | Cases | SSZ Dose (g/day) | ADR | Termination of Drug therapy | NAT2 | NAT1 | ||
---|---|---|---|---|---|---|---|---|
Genotypes | Acetylator genotypes | Genotypes | Acetylator genotypes | |||||
Dose-related | Case 1 | 3.0 | Nausea | No | NAT2*4/NAT2*7 | Fast | NAT1*10/NAT1*10 | Fast |
 | Case 2 | 3.0 | Nausea, anorexia | No | NAT2*4/NAT2*5 | Fast | NAT1*3/NAT1*10 | Fast |
 | Case 3 | 1.5 | Abdominal pain | Yes | NAT2*4/NAT2*6 | Fast | NAT1*4/NAT1*10 | Fast |
 | Case 4 | 3.0 | Diarrhea | Yes | NAT2*7/NAT2*7 | Slow | NAT1*4/NAT1*4 | Slow |
 | Case 5 | 3.0 | Diarrhea | No | NAT2*5/NAT2*7 | Slow | NAT1*4/NAT1*4 | Slow |
 | Case 6 | 3.0 | Epigastric discomfort | No | NAT2*4/NAT2*4 | Fast | NAT1*4/NAT1*10 | Fast |
 | Case 7 | 1.5 | Epigastric discomfort | Yes | NAT2*4/NAT2*7 | Fast | NAT1*4/NAT1*10 | Fast |
 | Case 8 | 1.5 | Increase in transaminases | Yes | NAT2*6/NAT2*7 | Slow | NAT1*4/NAT1*4 | Slow |
 | Case 9# | 2.25 | Increase in transaminases | Yes | NAT2*6/NAT2*7 | Slow | NAT1*4/NAT1*3 | Slow |
 | Case 10 | 2.25 | Dizziness | No | NAT2*6/NAT2*7 | Slow | NAT1*3/NAT1*3 | Slow |
 | Case 11 | 1.5 | Dizziness | Yes | NAT2*6/NAT2*6 | Slow | NAT1*4/NAT1*4 | Slow |
 | Case 12 | 1.5 | Dizziness | Yes | NAT2*5/NAT2*6 | Slow | NAT1*4/NAT1*4 | Slow |
 | Case 13 | 1.5 | Dizziness | Yes | NAT2*4/NAT2*7 | Fast | NAT1*10/NAT1*10 | Fast |
 | Case 14 | 1.5 | Dizziness | Yes | NAT2*6/NAT2*6 | Slow | NAT1*4/NAT1*4 | Slow |
 | Case 15 | 3.0 | Dizziness | No | NAT2*4/NAT2*4 | Fast | NAT1*4/NAT1*4 | Slow |
 | Case 16 | 1.5 | Chest congestion | Yes | NAT2*5/NAT2*6 | Slow | NAT1*4/NAT1*3 | Slow |
Non-dose-related | Case 17 | 2.25 | Leukopenia | Yes | NAT2*4/NAT2*6 | Fast | NAT1*4/NAT1*4 | Slow |
 | Case 18 | 1.5 | Rash | Yes | NAT2*6/NAT2*6 | Slow | NAT1*4/NAT1*4 | Slow |
 | Case 19 | 1.5 | Rash | Yes | NAT2*4/NAT2*6 | Fast | NAT1*3/NAT1*10 | Fast |
 | Case 20 | 1.5 | Rash | Yes | NAT2*4/NAT2*6 | Fast | NAT1*4/NAT1*11 | Slow |
 | Case 21 | 3.0 | Rash | Yes | NAT2*4/NAT2*4 | Fast | NAT1*4/NAT1*10 | Fast |
 | Case 22 | 3.0 | Rash | Yes | NAT2*4/NAT2*4 | Fast | NAT1*3/NAT1*10 | Fast |
 | Case 23 | 2.25 | Oral ulcer | Yes | NAT2*4/NAT2*4 | Fast | NAT1*10/NAT1*10 | Fast |
 | Case 24 | 2.25 | Oral ulcer | Yes | NAT2*4/NAT2*4 | Fast | NAT1*4/NAT1*10 | Fast |
Time-related | Case 25# | 2.25 | Cacospermia | Yes | NAT2*4/NAT2*6 | Fast | NAT1*3/NAT1*3 | Slow |