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Figure 4 | BMC Pharmacology and Toxicology

Figure 4

From: Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

Figure 4

Substrate binding pockets of (HUMAN)NAT1*4, (MOUSE)NAT2*1, (MESAU)NAT2*1 and (MOUSE)NAT2_F125S with 4ABglu docked. Maximised view of the active sites of (A): (HUMAN)NAT1*4; (B): (MOUSE)NAT2*1; (C): (MESAU)NAT2*1; (D) (MOUSE)NAT2_F125S with the arylamine substrate 4ABglu docked. The overall structure of each NAT enzyme is drawn as a ribbon diagram: (HUMAN)NAT1*4 is coloured in green [PDB:2PQT] [9] (MOUSE)NAT2*1 model in dark blue, (MESAU)NAT2*1 model in cyan and (MOUSE)NAT2_F125S model in pale blue. The side chains of the key residues involved in substrate binding within the active site are drawn in stick representation and labelled with carbon atoms in the corresponding colour of the enzyme, nitrogen in blue, oxygen in red and sulphur in yellow. The arylamine substrate 4ABglu is labelled with carbon atoms in orange, nitrogen in blue, oxygen in red and polar hydrogen in gray. The figures were generated using PyMOL [41].

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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