NAT enzymes: % specific activity values | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
(HUMAN) NAT1*4 | (MOUSE) NAT2*1 | (MESAU) NAT2*1 | (MOUSE) NAT2 F125S | (MOUSE) NAT2 R127G | (MOUSE) NAT2 R127L | (MOUSE) NAT1*1 | (HUMAN) NAT2*4 | |||
NAT substrates | F125 | - | - | S | - | - | Y | S | ||
R127 | - | - | - | G | L | G | S | |||
Y129 | - | L | - | - | - | - | S | |||
Negatively charged arylamines at pH 8.0 | Folate catabolites | 4AB glu | 20 ± 1 | 87 ± 1 | 57 ± 3 | 19 ± 1 | 9 ± 1 | 8 ± 1 | 8 ± 7 | 3 ± 1 |
4ABA | 100 ± 2 | 100 ± 2 | 100 ± 6 | 70 ± 2 | 8 ± 1 | 8 ± 1 | 48 ± 6 | 6 ± 1 | ||
Salicylic acids | 4AS | 67 ± 2 | 55 ± 1 | 74 ± 3 | 75 ± 3 | 27 ± 1 | 13 ± 1 | 88 ± 6 | 7 ± 1 | |
5AS | 64 ± 3 | 37 ± 1 | 30 ± 1 | 74 ± 1 | 94 ± 1 | 65 ± 9 | 76 ± 6 | 64 ± 2 | ||
Neutral electron-rich arylamines at pH 8.0 | Halogenated anilines | 4CA | 36 ± 2 | 46 ± 4 | 61 ± 2 | 56 ± 2 | 54 ± 3 | 70 ± 1 | 18 ± 3 | 71 ± 3 |
4BA | 50 ± 1 | 52 ± 2 | 72 ± 1 | 47 ± 2 | 70 ± 1 | 81 ± 11 | 28 ± 6 | 72 ± 1 | ||
4IA | 63 ± 1 | 72 ± 3 | 81 ± 1 | 69 ± 2 | 97 ± 1 | 74 ± 8 | 28 ± 3 | 65 ± 2 | ||
Alkyl- and aryl-oxyanilines | ANS | 56 ± 2 | 88 ± 6 | 89 ± 1 | 100 ± 3 | 97 ± 4 | 77 ± 10 | 48 ± 1 | 9 ± 2 | |
4AV | 25 ± 2 | 90 ± 1 | 32 ± 1 | 90 ± 1 | 66 ± 3 | 100 ± 10 | 28 ± 6 | 57 ± 3 | ||
HOA | 12 ± 4 | 23 ± 2 | 35 ± 1 | 47 ± 1 | 59 ± 3 | 80 ± 8 | 3 ± 4 | 51 ± 2 | ||
POA | 17 ± 7 | 20 ± 2 | 22 ± 1 | 62 ± 2 | 67 ± 1 | 61 ± 2 | 6 ± 1 | 62 ± 11 | ||
Other aniline | SMZ | 1 ± 1 | 4 ± 1 | 1 ± 1 | 1 ± 1 | 19 ± 2 | 3 ± 1 | 88 ± 6 | 46 ± 1 | |
Arylhydrazines | INH | 0 ± 2 | 2 ± 2 | 1 ± 1 | 38 ± 2 | 63 ± 10 | 76 ± 14 | 100 ± 6 | 62 ± 2 | |
HDZ | 2 ± 1 | 8 ± 2 | 3 ± 1 | 19 ± 1 | 100 ± 2 | 95 ± 1 | 68 ± 6 | 100 ± 1 |