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Table 5 Alkaline phosphatase (U/liter) assayed in blood of both female and male rats treated subcutaneously for 28 days with 20, 100 or 500 μg/kg/day with BK0023 or Neupogen ®

From: Preclinical and clinical phase I studies of a new recombinant Filgrastim (BK0023) in comparison with Neupogen®

Dose

Control

BK0023

Neupogen®

 

Males

Females

Males

Females

Males

Females

0 μg/kg/day

440 ± 110

264 ± 69

    

20 μg/kg/day

-

-

669* ± 130

429 ± 135

773** ± 90

400** ± 50

100 μg/kg/day

-

-

1365** ± 303

747** ± 212

1022** ± 127

855** ± 166

500 μg/kg/day

-

-

2109.** ± 538

1227** ± 268

2378.** ± 647

1005** ± 367

  1. Data are reported as mean values ± SD.
  2. * = mean value of group is significantly different from the control group at P < 0.05.
  3. ** = mean value of group is significantly different from the control group at P < 0.01.
  4. Statistical analysis was performed according to Dunnett’s test.
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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