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Table 5 The predictive factors of ΔCrCl according to univariate and multivariate analyses

From: Magnesium supplementation and high volume hydration reduce the renal toxicity caused by cisplatin-based chemotherapy in patients with lung cancer: a toxicity study

 

Univariate analysis

Maltivariate

 

Coefficient [95% CI]

P value

Coefficient [95% CI]

P value

Age (per 5 years)

−1.15 [−3.74 to 1.43]

0.375

−1.58 [−3.74 to 0.58]

0.149

Female (vs male)

5.03 [−2.40 to 12.46]

0.182

5.63 [−1.64 to 12.91]

0.127

PS 1 (vs PS 0)

9.16 [−1.37 to 19.68]

0.087

3.34 [−4.82 to 11.49]

0.418

Serum albumin

−3.53 [−11.89 to 4.84]

0.404

−1.28 [−9.14 to 6.59]

0.747

Cisplatin dose (per 5 mg/ml)

−1.41 [−1.57 to 4.38]

0.348

1.24 [−1.40 to 3.90]

0.35

Regular use drug

    

 NSAIDs

7.63 [−1.75 to 17.02]

0.109

2.98 [−5.25 to 11.21]

0.473

 Mg for purgative

0.54 [−7.25 to 8.34]

0.89

−3.67 [−10.10 to 2.76]

0.259

Anorexia (grade 2 or more)

−2.13 [−9.51 to 5.24]

0.566

2.19 [−5.31 to 9.70]

0.562

Mg infusion

−14.73 [−21.25 to −8.21]

<0.001

−15.28 [−21.99 to −8.57]

<0.001

Low volume hydration

−3.40 [−11.33 to 4.53]

0.396

22.31 [9.16 to 35.46]

0.001

  1. CI, confidential interval; PS, performance status; NSAIDs, non-steroid anti-Inflammatory drugs; Mg for purgative, Magnesium containing medications for purgative.