Skip to main content

Table 5 The predictive factors of ΔCrCl according to univariate and multivariate analyses

From: Magnesium supplementation and high volume hydration reduce the renal toxicity caused by cisplatin-based chemotherapy in patients with lung cancer: a toxicity study

  Univariate analysis Maltivariate
  Coefficient [95% CI] P value Coefficient [95% CI] P value
Age (per 5 years) −1.15 [−3.74 to 1.43] 0.375 −1.58 [−3.74 to 0.58] 0.149
Female (vs male) 5.03 [−2.40 to 12.46] 0.182 5.63 [−1.64 to 12.91] 0.127
PS 1 (vs PS 0) 9.16 [−1.37 to 19.68] 0.087 3.34 [−4.82 to 11.49] 0.418
Serum albumin −3.53 [−11.89 to 4.84] 0.404 −1.28 [−9.14 to 6.59] 0.747
Cisplatin dose (per 5 mg/ml) −1.41 [−1.57 to 4.38] 0.348 1.24 [−1.40 to 3.90] 0.35
Regular use drug     
 NSAIDs 7.63 [−1.75 to 17.02] 0.109 2.98 [−5.25 to 11.21] 0.473
 Mg for purgative 0.54 [−7.25 to 8.34] 0.89 −3.67 [−10.10 to 2.76] 0.259
Anorexia (grade 2 or more) −2.13 [−9.51 to 5.24] 0.566 2.19 [−5.31 to 9.70] 0.562
Mg infusion −14.73 [−21.25 to −8.21] <0.001 −15.28 [−21.99 to −8.57] <0.001
Low volume hydration −3.40 [−11.33 to 4.53] 0.396 22.31 [9.16 to 35.46] 0.001
  1. CI, confidential interval; PS, performance status; NSAIDs, non-steroid anti-Inflammatory drugs; Mg for purgative, Magnesium containing medications for purgative.