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Table 5 Drug-related problems derived from randomly selected antibacterial prescriptions for outpatients

From: An outpatient antibacterial stewardship intervention during the journey to JCI accreditation

Indicators

First phase

Second phase

(March, 2012)

(March, 2013)

Number of randomly selected antibacterial prescriptions for outpatients*

559

446

Number of DRPs

76

18

Occurrence rate of DRPS#

13.6%

4.0%

Occurrence rate of DRPs made by surgeons∆#

19.5%

5.6%

Occurrence rate of DRPs made by internal medicine physicians#

8.4%

2.8%

Occurrence rate of each subtype of DRP

  

(1) Inappropriate coadministration with non-antibacterials

4 (0.7%)

6 (1.3%)

(2) Inappropriate co-medication with other antibacterials#

17 (3.0%)

3 (0.7%)

(3) Inappropriate dosing frequency

8 (1.4%)

3 (0.7%)

(4) Inappropriate dose

1 (0.2%)

2 (0.4%)

(5) Inappropriate administration route

1 (0.2%)

0

(6) Use beyond approved indications

1 (0.2%)

2 (0.4%)

(7) Discordance between diagnosis and purpose of medication use

8 (1.4%)

2 (0.4%)

(8) Mismatches between antibacterial spectrum and the patient’s infection#

15 (2.7%)

0

(9) Abuse of i.v. medications instead of oral alternatives#

16 (2.9%)

0

(10) No diluent for i.v. antibacterials

1 (0.2%)

0

(11) Ignorance of patient’s other diseases

4 (0.7%)

0

  1. Notes: # P < 0.01 (first phase vs second phase). P < 0.01 (surgeons vs internal medicine physicians). Differences between two groups were tested for statistical significance using Pearson’s Chi-square test. A P value < 0.05 was considered to be statistically significant. A P value < 0.01 was considered to be highly significant. DRPs: drug-related problems.