Table 1 Symbolic notations used and corresponding units

Insulin aggregation kinetics measured by absorbance or fluorescence

X :

Amyloid aggregation growth measured as absorbance at 600 nm, relative ThT fluorescence intensity (%) and ThT fluorescence intensity at 482 nm or 490 nm. Units: absorbance units (AU) or (%).

t :

Time. Units: h or d

X _m :

Maximum aggregation growth. Units: AU or %

v _m :

Maximum aggregation rate. Units: AU h⁻¹, AU d⁻¹ or % h⁻¹

λ :

Lag phase. Units: h or d

X _m • :

Maximum insulin aggregation affected by chemical agent. Units: AU or %

v _m • :

Maximum insulin aggregation rate affected by chemical agent. Units: AU h⁻¹, AU d⁻¹ or % h⁻¹

λ• :

Lag phase affected by chemical agent. Units: h or d

Concentration effects on insulin aggregation kinetics

C :

Concentration of chemical agent. Units: mM or μM

K _x :

Maximum response affecting on X _m . Dimensionless

m _x :

Concentration corresponding to the semi-maximum response affecting on X _m . Units: mM or μM

a _x :

Shape parameter affecting on X _m . Dimensionless

K _v :

Maximum response affecting on v _m . Dimensionless

m _v :

Concentration corresponding to the semi-maximum response affecting on v _m . Units: mM or μM

a _v :

Shape parameter affecting on v _m . Dimensionless

K _λ :

Maximum response affecting on λ. Dimensionless

m _λ :

Concentration corresponding to the semi-maximum response affecting on λ. Units: mM or μM

a _λ :

Shape parameter affecting on λ. Dimensionless