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Table 3 Parametric estimates and confidence intervals (α = 0.05) from the equation ( 1) applied to the aggregation insulin increased data influenced by EGCG_1, EGCG_2, di-C7-PC and methylglyoxal concentrations

From: Modeling of chemical inhibition from amyloid protein aggregation kinetics

Parameters EGCG_1 EGCG_2 di-C7-PC Methylglyoxal
Aggregation model X m (AU or %) 1.12±0.03 1.28±0.06 99.85±4.91 541.20±11.38
  v m (AU h−1 or % h−1) 0.18±0.01 0.25±0.04 1.55±0.27 219.68±20.98
  λ (h) 4.78±0.28 53.34±0.28 124.62±5.86 2.92±0.12
Effect on X m K x 0.43±0.03 0.94±0.02 0.75±0.05 1.00±0.44
  m x (mM) 0.68±0.08 0.01±0.00 0.65±0.12 1.80±1.25
  a x 1.65±0.45 0.96±0.20 4.04±2.37 0.99±0.23
Effect on v m K v NS NS 0.86±0.04 0.99±0.01
  m v (mM) NS NS 0.47±0.06 0.42±0.07
  a v NS NS 2.51±2.35 0.74±0.08
Effect on λ K λ 0.81±0.10 NS NS NS
  m λ (mM) 0.50±0.08 NS NS NS
  a λ 0.98±0.24 NS NS NS
  EC 50,τ (mM) 0.44 0.006 0.47 0.33
  τ (h) 7.65 55.02 150.68 3.92
  p-value <0.001 <0.001 <0.001 <0.001
  B f 0.88 0.80 1.00 1.04
  A f 1.23 1.40 1.18 1.15
  R 2 adj 0.992 0.977 0.984 0.974
  1. Statistical values of adjusted coefficient of multiple determination (R 2 adj ) and p-values from Fisher’s F-test (α = 0.05). B f and A f are the bias and accuracy factor, respectively. NS: non-significant.