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Table 4 Parametric estimates and confidence intervals (α = 0.05) from the equation ( 1) applied to the aggregation of Aβ42-amyloid protein increased data influenced by apigenin, ectoine, hidroxyectoine and taiwaniaflavone concentrations

From: Modeling of chemical inhibition from amyloid protein aggregation kinetics

Parameters Apigenin Ectoine Hidroxyectoine Taiwaniaflavone Trehalose
Aggregation model X m (AU) 17.43±0.50 (5.07±0.23) × 10−3 (4.96±0.24) × 10−3 16.55±0.55 10.49±0.28
  v m (AU h−1 or AU d−1) 16.10±1.49 (0.24±0.05) × 10−3 (0.30±0.08) × 10−3 17.01±2.09 3.31±0.33
  λ (h or d) 0.25±0.03 11.60±2.26 13.50±2.31 0.27±0.06 5.76±0.14
Effect on X m K x 0.41±0.06 1.00±0.99 1.00±0.90 0.78±0.05 0.44±0.03
  m x (mM or μM) 6.52±1.93 11.82±11.03 66.70±65.78 2.32±0.38 51.58±7.27
  a x 0.91±0.25 0.19±0.13 0.43±0.43 0.98±0.16 1.36±0.31
Effect on v m K v 0.38±0.12 0.83±0.06 0.86±0.16 1.14±0.60 0.53±0.08
  m v (mM or μM) 9.29±5.35 0.33±0.32 1.35 (NS) 1.88±1.73 33.22±17.26
  a v 1.35±1.13 0.36±0.14 0.34±0.20 0.40±0.21 0.66±0.33
Effect on λ K λ 1.76±0.70 NS NS 1.27±1.13 NS
  m λ (mM or μM) 2.16±0.29 NS NS 2.53±1.45 NS
  a λ 2.39±0.99 NS NS 2.33±2.31 NS
  EC 50, τ (mM or μM) 2.45 0.96 2.20 0.91 21.43
  τ (h or d) 0.75 17.31 20.52 0.65 6.54
  p-value <0.001 <0.001 <0.001 <0.001 <0.001
  B f 0.99 1.04 1.00 1.02 1.03
  A f 1.06 1.09 1.18 1.11 1.08
  R 2 adj 0.995 0.988 0.984 0.990 0.995
  1. The case of apomyoglobin affected by trehalose is also shown. Statistical values of adjusted coefficient of multiple determination (R 2 adj ) and p-values from Fisher’s F-test (α = 0.05). B f and A f are the bias and accuracy factor, respectively. NS: non-significant.