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Table 1 Rare variants of sGC α1 subunit found in MI patients:

From: Functional evaluation of GUCY1A3 mutations associated with myocardial infarction risk

Variant Identified in Predicted effect on protein function
   PolyPhen-2 SIFT SNAP
p.Leu163Phefs*24 MI family frameshift - -
p.Lys53Glu 252 young MI cases possibly damaging damaging tolerated non-neutral
p.Thr64Ala 252 young MI cases benign tolerated neutral
p.Thr229Met 252 young MI cases possibly damaging tolerated non-neutral
p.Ser478Gly 252 young MI cases benign tolerated neutral
p.Val587Ile 252 young MI cases benign tolerated neutral
p.Gly573Arg MI family probably damaging affect protein function non-neutral
p.Cys610Tyr 252 young MI cases probably damaging tolerated neutral
p.Ile571Val 252 young MI cases possibly damaging affect protein function neutral