Skip to main content

Table 1

From: C-type natriuretic peptide chronic administration attenuates cardiac fibrosis and inflammation in spontaneously hypertensive rats

  W-S W-CNP SHR-S SHR-CNP
SBP 118±2 122±3 175±3* 159±5#
LMVI 0,023±0,002 0,024±0,001 0,032±0,001* 0,029±0,001
Myocyte area 349±11 337±10 609±25* 557±35#
% Fibrosis 1,54±0,53 1,78±0,17 6,81±0,40* 3,27±0,67#
IL-6 (IHC) 1,8±1,0 1,3±0,6 19,4±2,7* 2,1±0,7#
TNF-α (IHC) 1,1±0,7 1,0±0,5 15,7±3,4* 1,5±0,9#
IL-6 (ELISA) -- -- 100,1±6,2 81,0±9,0
TNF-α (ELISA) -- -- 8,27±0,89 4,32±0,18#
IL-1β (ELISA) -- -- 135,7±5,8 120,3±2,3#
  1. Values are means ± SEM.
  2. *p<0.01 vs W-S,
  3. # p<0.01 vs SHR-S.