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Figure 2 | BMC Pharmacology and Toxicology

Figure 2

From: Roles of 8-nitro-cGMP in autophagy regulation

Figure 2

S -Guanylation promotes ubiquitination of invading bacteria. After escape of bacteria from endoosome into the cytosol, their surface is modified by 8-nitro-cGMP via protein S-guanylation, which promotes subsequent Lys63-linked polyubiquitination. Ubiquitin chain is a tag for selective transport of modified cargos to autophagosomes.

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