Figure 2From: Roles of 8-nitro-cGMP in autophagy regulationS -Guanylation promotes ubiquitination of invading bacteria. After escape of bacteria from endoosome into the cytosol, their surface is modified by 8-nitro-cGMP via protein S-guanylation, which promotes subsequent Lys63-linked polyubiquitination. Ubiquitin chain is a tag for selective transport of modified cargos to autophagosomes.Back to article page