Parameter | Unit | n | 2.4 mg high-concentration suspension fasted | n | 2.4 mg high-concentration suspension fed | n | 0.3 mg high-concentration suspension fasted | n | 0.15 mg low-concentration suspension fasted | n | mgIR tablet fasted |
---|---|---|---|---|---|---|---|---|---|---|---|
AUC | μ*h/L | 29 | 781/49 (230–1515) | 29 | 663/45 (258–1212) | 27 | 91/43 (38–165) | 25 | 47/60 (8.3–91) | 29 | 311/46 (103–587) |
AUC/D | h/L | 29 | 0.33/49 (0.10–0.63) | 29 | 0.28/45 (0.12–0.50) | 27 | 0.30/43 (0.13–0.55) | 25 | 0.31/60 (0.056–0.61) | 29 | 0.31/46 (0.10–0.59) |
Cmax | μ/L | 29 | 78/31 (43–128) | 29 | 48/22 (32–70) | 29 | 9.8/33 (4.5–17) | 29 | 4.9/35 (1.9–8.1) | 29 | 36/30 (18–61) |
Cmax/D | 1/L | 29 | 0.03/31 (0.02–0.05) | 29 | 0.02/22 (0.01–0.29) | 29 | 0.03/33 (0.01–0.06) | 29 | 0.03/35 (0.01–0.05) | 29 | 0.04/30 (0.02–0.06) |
tmaxa | h | 29 | 1.5 (0.75–4.0) | 29 | 4.0 (3.0–12) | 29 | 1.0 (0.50–3.0) | 29 | 1.0 (0.50–4.0) | 29 | 1.0 (0.50–3.0) |
t1/2 | h | 29 | 9.2/41 (2.8–21) | 29 | 9.4/33 (4.2–17) | 27 | 7.8/39 (3.5–15) | 25 | 6.8/42 (2.5–12) | 29 | 7.9/43 (3.4–14) |