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Table 1 Examples for extracellular first messenger effects of cGMP:

From: Differentiation between first and second messenger effects of cGMP

Model

extracellular cGMP effect

Ref.

rat model of colorectal pain

analgesic (oral cGMP)

[7]

oxidative glutamate toxicity in HT22 cells

neuroprotective

[8]

kainate receptor-mediated neurotransmitter release

inhibition

[9]

glycine receptor-induced chloride current

accelerates desensitization

[10]