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Table 1 Examples for extracellular first messenger effects of cGMP:

From: Differentiation between first and second messenger effects of cGMP

Model extracellular cGMP effect Ref.
rat model of colorectal pain analgesic (oral cGMP) [7]
oxidative glutamate toxicity in HT22 cells neuroprotective [8]
kainate receptor-mediated neurotransmitter release inhibition [9]
glycine receptor-induced chloride current accelerates desensitization [10]