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Figure 1 | BMC Pharmacology and Toxicology

Figure 1

From: Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats

Figure 1

Aortic DHE fluorescence Effects of sGC activator BAY 60-2770 and sGC stimulator BAY 41-8543 in vivo treatment on oxidative stress parameters in tolerant rats. Quantification of vascular ROS formation in aortic cryo-sections was assessed by fluorescent microtopography using the superoxide-sensitive dye DHE (1 µM).

The data are the means ± SEM from 3-4 animals/group. *, p<0.05 vs. control; #, p<0.05 vs. GTN; $, p<0.05 vs. BAY 60-2770; ^, p<0.05 vs. low dose treatment.

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