Echocardiography | WT + saline (n=7) | sGCα1-/- + saline (n=6) | WT + DOX (n=12) | sGCα1-/- + DOX (n=11) |
---|---|---|---|---|
LVIDS (mm) | 1.3±0.1 | 1.3±0.0 | 1.7±0.1† | 2.0±0.1†* |
LVIDD (mm) | 3.0±0.0 | 3.0±0.0 | 3.2±0.1† | 3.3±0.0† |
FS (%) | 57±1 | 57±1 | 48±2† | 40±1†* |
HR (bpm) | 531±13 | 505±18 | 428±17† | 426±18† |
Hemodynamic measurements | WT + saline (n=6) | sGCα1-/- + saline (n=5) | WT + DOX (n=12) | sGCα1-/- + DOX (n=9) |
ESV (μl) | 19±1 | 19±1 | 26±3† | 37±3†* |
EDV (μl) | 43±2 | 41±2 | 51±2† | 58±2†* |
EF (%) | 60±2 | 58±3 | 55±4 | 42±3†* |
dP/dtmax (mmHg/s) | 13,499±1,433 | 11,995±601 | 13,503±678 | 10,386±875* |
dP/dtmin (mmHg/s) | -12,053±1,809 | -11,420±950 | -13,531±846 | -10,943±940¶ |
Tau (ms) | 5.1±0.1 | 4.9±0.2 | 5.6±0.2† | 6.3±0.3†¶ |
PRSW | 83±9 | 84±6 | 70±9 | 49±7†¶ |
Ees (mmHg/μl) | 6.3±1.2 | 7.3±1.4 | 4.0±0.8† | 2.3±0.3†¶ |
EDPVR (mmHg/μl) | 0.21±0.03 | 0.18±0.02 | 0.16±0.02 | 0.19±0.02 |
HR (bpm) | 576±8 | 614±12 | 528±9† | 530±14†* |