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Table 2 Association between log transformed EFV concentration and categorical explanatory variables.

From: CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe

Variable Mean Log EFV concentration p-value CV
Gender   0.195 74%
Male 1.68   
Female 1.46   
CYP 2B6*6   0.008* 68%
GG 1.16   
GT 1.55   
TT 2.35   
CYP 2B6*18   <0.001*** 69%
TT 1.35   
TC 2.22   
CC 3.01   
ABCB1 1236C/T   0.841 74%
CC 1.60   
CT 1.56   
TT 1.30   
CYP 2A6*9   0.004** 72%
GG 1.47   
AA 2.21   
CYP 2A6*17   0.694 74%
AA 1.92   
AG 1.45   
GG 1.62   
CNS Toxicity   0.122 73%
Yes 1.72   
No 1.43   
Regimen   0.619 73%
TDF/3TC/EFV 1.434   
AZT/3TC/EFV 1.510   
D4T/3TC/EFV 1.655   
ART Only 1.452 0.334 79%
ART + anti-TB Therapy 1.618   
  1. “*”p < 0.05, “**”p < 0.01, “***”p < 0.001; CV= coefficient of variation.