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Table 4 Table showing contribution of each covariate on improving the model fit and percentage of inter-individual variability on EFV clearance accounted for

From: CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe

Covariate Points decrease in OFVa DFb p-value IIV explained (%)c
CYP2B6*18 67.07 2 <0.0001 18.0
CYP2B6*6 36.03 2 <0.0001 16.4
Body weight 19.37 1 <0.0001 10.7
Sex 10.41 1 0.0013 9.9
Age 0.29000 1 0.590220 0.01
EFV-RIF interactiond 1.93200 1 0.164540 1.1
CNS effect 1.01100 1 0.314660 0.14
CYP2A6*9 3.83600 1 0.050163 2.7
CYP 2A6*17 1.44 2 0.230140 1.8
  1. aChange in NONMEM objective function value. bDegrees of freedom. cInter- individual variability. dInteraction between efavirenz and rifampicin.