TY - JOUR AU - Miller, Bruce E. AU - Mistry, Sunil AU - Smart, Kevin AU - Connolly, Paul AU - Carpenter, Donald C. AU - Cooray, Hiran AU - Bloomer, Jackie C. AU - Tal-Singer, Ruth AU - Lazaar, Aili L. PY - 2015 DA - 2015/06/20 TI - The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects JO - BMC Pharmacology and Toxicology SP - 18 VL - 16 IS - 1 AB - Excessive neutrophil presence and activation is important in a number of acute and chronic inflammatory diseases. The CXCR2 chemokine receptor is important in controlling the extravasation and activation of neutrophils. Selective antagonism of the CXCR2 receptor is a potential approach to reducing neutrophil migration and activation. Danirixin, is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine. SN - 2050-6511 UR - https://doi.org/10.1186/s40360-015-0017-x DO - 10.1186/s40360-015-0017-x ID - Miller2015 ER -