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Table 3 Composition of induced sputum (pre- vs. post-baseline ozone, n = 24)

From: Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial

   Visit 1 Visit 3
   Pre-ozone Post-Baseline Ozone
Viability % 85.2 (9.4) 89.3 (11.3)
TCC 106/mL 1.5 (0.9) 3.8 (3.6)***
WBC 106/mL 1.5 (1.0) 3.7 (3.8)***
Macrophages % nSq 70.2 (22.6) 25.2 (21.9)***
  % WBC 72.2 (28.0) 25.5 (23.7)***
  cells/g 1.0 (0.6) 0.7 (1.0)
CD14+ Monocytes % nSq 1.9 (1.9) 5.7 (2.4)***
  % WBC 1.9 (2.0) 5.7 (2.1)***
  cells/g 0.0 (0.1) 0.2 (0.2)***
Neutrophils % nSq 23.6 (21.6) 64.5 (27.3)***
  % WBC 24.4 (23.5) 67.0 (24.8)***
  cells/g 0.2 (0.6) 2.2 (2.4)***
Lymphocytes % nSq 1.5 (1.6) 0.6 (1.2)*
  %WBC 1.7 (1.5) 0.6 (1.2)*
  cells/g 0.0 (0.0) 0.0 (0.1)
Eosinophils % nSq 0.0 (0.5) 0.3 (0.5)
  % WBC 0.0 (0.5) 0.3 (0.6)
  cells/g 0.0 (0.0) 0.0 (0.0)
Epithelial cells % nSq 1.4 (4.9) 1.2 (1.4)
  cells/g 0.0 (0.1) 0.0 (0.0)
Squamous cells % 13.5 (16.2) 3.8 (8.2)
IL8 pg/ml 639.6 (496.5) 1101.8 (723.1)***
IL6 pg/ml 13.1 (9.1) 39.9 (49.4)***
IL1B pg/ml 22.8 (20.3) 36.2 (40.5)***
MMP9 ng/ml 50.9 (71.6) 152.6 (168.5)***
  1. Median and interquartile ranges
  2. TCC total cell count, WBC sputum white blood cells
  3. *p < 0.05, ***p < 0.001
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