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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: A novel nasal powder formulation of glucagon: toxicology studies in animal models

Fig. 4

Mean (+ SE) uncorrected glucagon serum concentration profiles in dogs following a single intra-nasal administration—Day 1. Glucagon concentrations on Day 1 (linear scale). Levels were below the LLOQ (200 pg/mL) in all samples collected in the placebo-powder group on Day 1. Following a single GNP intra-nasal dose, mean glucagon concentration levels increased quickly to reach peak levels within 10 min and declined over the sampling interval. Mean peak glucagon levels were similar across GNP dose levels

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