Table 1 Pivotal toxicology studies conducted with the GNP drug product
From: A novel nasal powder formulation of glucagon: toxicology studies in animal models
Study type | Species/N/Gender | Test articles and dosage |
|---|---|---|
28-day sub-chronic toxicology | Rat/71M/71F | Saline, placebo liquid, GNP ingredients in solution at 0.1 and 0.2 mg/rat/day for 28 days |
28-day sub-chronic toxicology | Dog/16M/16F | Saline, placebo powder, GNP at 2 and 4 mg/dog/day for 28 days |
Acute toxicology | Rat/16M/16F | Air placebo control, GNP at 0.5 mg intra-tracheally |
Acute toxicology | Rabbit | 30-mg drug product administered directly in eye |