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Table 3 Summary of hematology, coagulation, clinical chemistry, and urinalysis data in dogs, Day 29 relative to start datea

From: A novel nasal powder formulation of glucagon: toxicology studies in animal models

Parameter Group 1: Placebo control Group 2: Saline control Group 3: Low dose Group 4: High dose
    Hematology      
  Male (N = 9) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 9) Male (N = 8) Female (N = 9)
 Red blood cells (1012/L) 8.62 (0.433) 8.08 (0.378) 8.52 (0.298) 8.14 (0.236) 8.59 (0.441) 8.19 (0.393) 8.49 (0.379) 8.26 (0.267)
 Hemoglobin (g/L) 149 (6.8) 142 (6.2) 148 (5.7) 144 (3.1) 149 (6.7) 144 (6.4) 147 (7.7) 144 (3.7)
 Hematocrit (L/L) 0.47 (0.019) 0.44 (0.015) 0.47 (0.019) 0.45 (0.010) 0.47 (0.023) 0.44 (0.021) 0.47 (0.027) 0.45 (0.011)
 Mean corpuscular volume (fL) 55.1 (1.69) 54.5 (1.45) 55.4 (1.16) 55.1 (1.05) 55.0 (1.21) 54.3 (1.22) 55.1 (2.07) 54.7 (1.58)
 Mean corpuscular hemoglobin (pg) 17.3 (0.35) 17.6 (0.52) 17.4 (0.25) 17.7 (0.41) 17.3 (0.37) 17.5 (0.42) 17.3 (0.71) 17.4 (0.40)
 Mean corpuscular hemoglobin concentration (g/L) 314 (4.6) 323 (7.1) 314 (3.0) 321 (4.1) 315 (3.9) 323 (5.0) 313 (6.5) 319 (6.3)
 Platelets (109/L) 926 (148.3) 941 (105.1) 966 (186.9) 887 (123.7) 895 (169.0) 901 (136.8) 864 (122.1) 821 (194.5)
 % Reticulocytes (%) 1.79 (0.652) 1.66 (0.517) 1.95 (0.477) 1.57 (0.381) 2.01 (0.377) 1.76 (0.463) 1.83 (0.320) 1.66 (0.457)
 Reticulocytes (1012/L) 0.152 (0.0491) 0.133 (0.0379) 0.165 (0.0364) 0.128 (0.0318) 0.171 (0.0219) 0.143 (0.0363) 0.155 (0.0257) 0.136 (0.0363)
 White blood cells (109/L) 8.44 (1.498) 5.56 (1.867) 9.08 (1.476) 6.92 (1.547) 9.41 (2.417) 6.28 (2.144) 8.90 (2.046) 5.00 (1.472)
 Neutrophils (109/L) 0.74 (0.188) 0.40 (0.165) 0.82 (0.299) 0.39 (0.109) 0.85 (0.263) 0.47 (0.114) 0.82 (0.264) 0.43 (0.140)
 Lymphocytes (109/L) 7.40 (1.349) 4.94 (1.803) 7.89 (1.294) 6.21 (1.362) 8.20 (2.338) 5.59 (1.997) 7.73 (2.029) 4.37 (1.432)
 Monocytes (109/L) 0.13 (0.049) 0.11 (0.060) 0.19 (0.044) 0.16 (0.070) 0.18 (0.058) 0.10 (0.027) 0.19 (0.080) 0.09 (0.039)
 Eosinophils (109/L) 0.10 (0.026) 0.07 (0.023) 0.11 (0.040) 0.09 (0.034) 0.10 (0.033) 0.08 (0.017) 0.09 (0.027) 0.07 (0.033)
 Basophils (109/L) 0.03 (0.010) 0.02 (0.007) 0.03 (0.010) 0.02 (0.007) 0.03 (0.019) 0.02 (0.011) 0.03 (0.012) 0.02 (0.010)
 Leucocytes (109/L) 0.04 (0.012) 0.03 (0.015) 0.04 (0.017) 0.05 (0.039) 0.05 (0.033) 0.03 (0.027) 0.05 (0.022) 0.02 (0.011)
Coagulation
  Male (N = 9) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 9) Male (N = 8) Female (N = 9)
 Prothrombin time (Sec) 13.5 (0.53) 13.3 (0.54) 13.4 (0.35) 13.7 (0.53) 13.3 (0.34) 13.5 (0.34) 13.6 (0.41) 13.7 (0.39)
 Activated partial thromboplastin time (Sec) 17.1 (1.28) 15.5 (2.78) (N = 9) 16.5 (1.03) 16.6 (1.25) 16.8 (1.68) 16.2 (0.97) 16.1 (0.68) 16.2 (1.05)
Clinical chemistry
  Male (N = 9) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 10)
 Alanine transaminase (U/L) 27 (4.5) 29 (8.7) 30 (5.4) 30 (7.4) 31 (8.7) 34 (14.3) 28 (7.1) 31 (9.9)
 Aspartate aminotransferase (U/L) 138 (35.4) 114 (18.1) 124 (30.3) 120 (25.5) 148 (24.0) 135 (44.6) 130 (26.9) 120 (49.3)
 Alkaline phosphatase (U/L) 140 (25.9) 70 (17.9) 139 (19.9) 70 (12.2) 135 (28.3) 65 (15.5) 127 (30.3) 55 (12.9)
 Total bilirubin (μmolL) 2.1 (0.58) (N = 3) 1.9 (0.14) (N = 2) 2.0 (0.21) (N = 2) 1.9 (0.00) (N = 2) 1.9 (−) (N = 1) 2.1 (0.21) (N = 3) 2.2 (−) (N = 1) 2.2 (0.29) (N = 4)
 Cholesterol (mmol/L) 1.80 (0.561) 1.85 (0.432) 1.67 (0.311) 1.84 (0.354) 1.49 (0.416) 2.0 (0.453) 1.76 (0.288) 1.75 (0.313)
 Triglycerides (mmol/L) 0.57 (0.252) 0.28 (0.050) 0.57 (0.136) 0.36 (0.113) 0.55 (0.229) 0.38 (0.108) 0.57 (0.203) 0.34 (0.088)
 Glucose (mmol/L) 7.5 (1.06) 6.9 (1.75) 7.1 (0.85) 8.5 (1.85) 7.4 (0.92) 8.1 (2.19) 8.4 (2.41) 9.1 (1.37)
 Total protein (g/L) 59 (4.0) 61 (5.8) 59 (2.2) 62 (2.9) 59 (3.2) 64 (3.5) 61 (2.0) 65 (4.5)
 Albumin (g/L) 39 (2.3) 44 (4.1) 39 (0.9) 43 (1.8) 38 (2.6) 45 (2.5) 39 (1.7) 48 (5.0)
 Globulin (g/L) 20 (2.4) 17 (2.4) 21 (1.5) 19 (2.1) 21 (2.1) 19 (1.5) 22 (2.4) 18 (2.0)
 Albumin/Globulin ratio 2.0 (0.24) 2.6 (0.30) 1.9 (0.12) 2.3 (0.26) 1.8 (0.23) 2.4 (0.17) 1.8 (0.24) 2.7 (0.53)
 Urea (mmol/L) 5.0 (0.78) 5.4 (0.87) 4.6 (0.67) 5.2 (0.69) 5.1 (0.87) 5.8 (1.01) 5.6 (0.90) 5.1 (0.40)
 Creatinine (μmolL) 22 (3.3) 28 (2.5) 21 (3.0) 28 (5.1) 25 (2.9) 28 (5.5) 26 (2.0) 29 (3.0)
 Calcium (mmol/L) 2.55 (0.116) 2.52 (0.064) 2.60 (0.044) 2.57 (0.069) 2.59 (0.080) 2.63 (0.093) 2.60 (0.077) 2.68 (0.075)
 Phosphate (mmol/L) 2.45 (0.162) 2.07 (0.126) 2.53 (0.145) 2.06 (0.249) 2.54 (0.174) 2.10 (0.224) 2.54 (0.269) 2.06 (0.213)
 Sodium (mmol/L) 143 (1.1) 143 (1.7) 144 (1.5) 142 (1.8) 146 (1.0) 145 (2.1) 147 (1.4) 146 (1.4)
 Potassium (mmol/L) 5.1 (0.20) 4.7 (0.39) 5.0 (0.31) 5.1 (0.35) 5.2 (0.32) 5.0 (0.47) 5.3 (0.60) 4.8 (0.26)
 Chloride (mmol/L) 102 (1.9) 105 (1.9) 102 (1.6) 104 (2.3) 104 (0.9) 105 (1.6) 104 (1.7) 105 (1.3)
 Urinalysis
  Male (N = 9) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 10) Male (N = 10) Female (N = 9)
 Volume (mL) 7 (3.5) 7 (5.6) 9 (2.9) 5 (2.6) 7 (5.4) 5 (2.4) 10 (3.8) 9 (6.7)
 Specific gravity 1.030 (0.0090) 1.028 (0.0138) 1.024 (0.0077) 1.027 (0.0083) 1.027 (0.0112) 1.026 (0.0079) 1.024 (0.0068) 1.021 (0.0156)
  1. aAll data are presented as mean (standard deviation)