Table 5 Baseline-corrected toxicokinetic parameters of glucagon in dogs
From: A novel nasal powder formulation of glucagon: toxicology studies in animal models
Parameters | Mean (% CV) | |||
|---|---|---|---|---|
Day 1 | Day 28 | |||
GNP 2 mg/day | GNP 4 mg/day | GNP 2 mg/day | GNP 4 mg/day | |
N | 6 | 6 | 6 | 6 |
AUC0–90 (pg min/mL) | 229,465 (27.9) | 151,619 (52.1) | 267,261 (41.6) | 345,747 (61.4) |
AUC0-t (pg min/mL) | 213,385 (15.8) | 148,561 (52.7) | 267,261 (41.6) | 343,597 (62.4) |
Cmax (pg/mL) | 6984 (26.0) | 7251 (50.6) | 8684 (34.1) | 13,171 (56.4) |
Tmaxa (min) | 10.0 (10.0, 20.0) | 10.0 (5.00, 20.0) | 10.0 (5.00, 10.0) | 10.0 (5.00, 20.0) |
T1/2 (min) | NC (NC)b | 11.4 (NC)c | 21.1 (18.4)d | 7.79 (NC)e |