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Table 5 Baseline-corrected toxicokinetic parameters of glucagon in dogs

From: A novel nasal powder formulation of glucagon: toxicology studies in animal models

Parameters Mean (% CV)
Day 1 Day 28
GNP 2 mg/day GNP 4 mg/day GNP 2 mg/day GNP 4 mg/day
N 6 6 6 6
AUC0–90 (pg min/mL) 229,465 (27.9) 151,619 (52.1) 267,261 (41.6) 345,747 (61.4)
AUC0-t (pg min/mL) 213,385 (15.8) 148,561 (52.7) 267,261 (41.6) 343,597 (62.4)
Cmax (pg/mL) 6984 (26.0) 7251 (50.6) 8684 (34.1) 13,171 (56.4)
Tmaxa (min) 10.0 (10.0, 20.0) 10.0 (5.00, 20.0) 10.0 (5.00, 10.0) 10.0 (5.00, 20.0)
T1/2 (min) NC (NC)b 11.4 (NC)c 21.1 (18.4)d 7.79 (NC)e
  1. NC not calculated
  2. aMedian (Min, Max); bn = 0; cn = 2; dn = 4; en = 1