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Table 3 Clinical features of the three patients who developed nephrotoxicity

From: Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand

Baseline characteristics before treatment

 N

1

2

3

 Age (years)

68

54

66

 Sex

M

F

M

 Weight (kg)

79

54

60

 Hypertension

Yes

No

No

 Diabetes mellitus

Yes

No

No

 Cirrhotic

No

No

No

 Serum creatinine concentration (mg/dl)

1.1

0.8

1.1

 Treatment

LAM + ADV

ADV

ADV

 Treatment duration (months)

71

44

101

Results at the diagnosis of nephrotoxicity

 Serum creatinine concentration (mg/dl)

1.7

1.4

1.6

 Proteinuria

No

No

No

 Glucosuria

No

No

No

Action

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ADVa

ADVb

ADVb

  1. N patient number, Cr serum creatinine concentration, LAM lamivudine, ADV adefovir
  2. aChange; bAdjusted dosage interval to 10 mg every 48 hours according to eGFR