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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Heme oxygenase-1 attenuates cadmium-induced mitochondrial-caspase 3- dependent apoptosis in human hepatoma cell line

Fig. 3

HO-1 attenuates Cd-induced oxidative stress. HepG2 cells were either treated with 5 and 10 μM CdCl2 for 1 h or pre-treated with either 10 μM CoPPIX or 10 μM SnPPIX for 24 h before exposure to 5 and 10 μM CdCl2 for 1 h. ROS levels were determined by the H2FDA method as described in the Materials and methods. Values shown are mean ± SD of three different experiments done in triplicate (n = 3). # p < 0.0001 as significant differences between Cd-treated and control. *** p < 0.001 as a significant difference between pre-treated and non pre-treated cells

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