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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp

Fig. 2

Inhibition of hERG currents by various hERG channel blockers. hERG currents on HEK 293 cells expressed hERG gene were detected by an automated 384-well-patch-clamp system. hERG currents were inhibited concentration-dependently by five hERG channel blockers, astemizole (a), cisapride (b), E-4031 (c), quinidine (d), and terfenadine (e). Left and right panels show the representative recordings of hERG current inhibition and the inhibitory curves of hERG currents, respectively. The 50 % inhibitory concentrations (IC50) were analyzed and shown in the left upper sides of the right panels. The n numbers were total numbers of cells at all concentrations of each drug. Three hundred eighty-four points were divided into six, and five hERG channel blockers and no blocker were added. The error bars in the right panels show means ± SD and IC50 values show means

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