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Table 1 Baseline characteristics of the aspirin and non-aspirin therapy groups

From: Association between aspirin therapy and the outcome in critically ill patients: a nested cohort study

Variable

Aspirin

N = 154

Non-aspirin

N = 609

Crude

P value

PS adjusted

P-Value

Age (yrs) mean ± SD

65 ± 16.5

48.8 ± 21.7

<0.0001

0.88

Gender, n (%)

    

 Female

56 (36.4)

152 (25)

0.005

0.97

 Male

98 (63.6)

457 (75.1)

  

Diabetes, n (%)

102 (66.2)

201 (33.8)

0.0001

0.22

Admission category, n (%)

    

 Non-operative

145 (94.2)

495 (81.3)

0.0001

0.21

 Post-operative

9 (5.8)

114 (18.7)

  

APACHE II, mean ± SD

26.5 ± 7.2

22.9 ± 8.2

<0.0001

0.67

Mechanical ventilation, n (%)

135 (87.7)

548 (90)

0.40

0.93

SOFA on day 1, mean ± SD

9.3 ± 3.3

9.2 ± 3.5

0.82

0.52

Sepsis, n (%)

47 (30.5)

147 (24.1)

0.104

0.68

Chronic respiratory disease, n (%)

43 (27.9)

114 (18.7)

0.011

0.19

Chronic cardiac disease n (%)

76 (49.4)

81 (13.3)

<0.0001

0.86

Chronic liver disease n (%)

9 (5.8)

45 (7.4)

0.50

0.54

Chronic immunosuppression n (%)

11 (7.1)

55 (9.1)

0.45

0.30

Chronic renal disease n%

38 (24.7)

65 (10.7)

0.0001

0.43

GCS, mean ± SD

9.0 ± 4.2

8.6 ± 4.1

0.23

0.70

Vasopressor, n (%)

106 (68.8)

390 (64.1)

0.26

0.36

PaO2/FiO2 ratio, mean ± SD

200 ± 98

221 ± 119

0.04

0.88

Statin use n%

74 (48.1)

33 (5.4)

<0.0001

0.83

Bilirubin (μmol/L), mean ± SDa

31.2 ± 69.4

36.1 ± 70

0.50

0.26

Creatinine (μmol/L), mean ± SDa

199.9 ± 171.2

148.8 ± 146.5

0.0002

0.15

INR, mean ± SD

1.5 ± 0.8

1.5 ± 0.9

0.73

0.26

Platelet, x 109/L mean ± SD

193.1 ± 121

247.9 ± 133.3

<0.0001

0.048

  1. P-values are provided for the differences between the two groups significant before and after propensity score adjustment
  2. APACHE Acute physiology and chronic health evaluation, GCS Glasgow coma scale, INR International normalized ratio, PS propensity score, SOFA Sequential Organ Failure Assessment
  3. aTo convert to conventional units in mg/dL, divide by 88.4 for creatinine and 17.1 for bilirubin