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Table 1 Pharmacokinetic variables of 10 mg of oral melatonin

From: Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

t 1/2 absorption min t max min C max pg mL-1 t 1/2 elimination min AUC 0-∞ oral pg ml-1 min f %
6.0 (3.1) 40.8 (17.8) 3550.5 (2500.5–8057.5) 53.7 (7.0) 281,538.3 (232,696.1–546,285.4) 2.5 (1.7–4.7)
  1. Absorption half-life, time to maximal concentration and elimination half-life data are presented as mean (SD). Maximal concentration, area-under-the-curve and bioavailability data are presented as median (IQR)
  2. Absorption half-life, t 1/2 absorption; time to maximal concentration, t max; maximal plasma concentration, C max; elimination half-life, t 1/2 elimination; area-under-the-curve, AUC; bioavailability, f